In adults, single doses above 10 grams or 140 mg kg have reasonable likelihood of causing toxicity. As result, hepatocellular supplies of glutathione become exhausted and NAPQI is free to react with cellular membrane molecules, resulting in widespread hepatocyte damage and death, clinically leading to acute hepatic necrosis. FDA continues to assess the safety and efficacy of these products and to revise its OTC list of approved ingredients and amounts for these medicines. However, if taken in excess amounts overdose, whether on purpose or by accident acetaminophen can cause life-threatening illness. In case of emergency overdose Return to top In case of overdose, call your local poison can you overdose on acetaminophen control center at 1-800-222-1222. If you are using the medication regularly, use the missed dose as soon as you remember. What other drugs ordain modify acetaminophen? There may be other drugs that can interact with acetaminophen.